Christina Haston is an associate professor of medical physics at UBC’s Okanagan campus. - Credit: UBCO

UBC study could spare cancer patients from side effects of radiation

Her research has drawn a connection of Chromosome 6 genes to pulmonary fibrosis susceptibility.

A UBC Okanagan researcher has determined that genes on a specific chromosome may be the answer as to why thoracic radiotherapy leads to a lung injury in some lung cancer patients.

Christina Haston, an associate professor of medical physics, recently published a study examining how Chromosome 6 can contribute to radiation-induced pulmonary fibrosis. Her study finds that genetic differences can determine whether or not this lung injury follows radiotherapy in an experimental system, according to UBCO in a news release.

“Currently, 50 per cent of cancer patients in Canada receive radiation therapy as part of their treatment course,” she said. “In addition to effects on the tumour, up to 30 per cent of these patients develop side effects to this treatment, or injuries to non-tumour tissue.”

RELATED: UBC Okanagan study evaluates virtual educational care

Pulmonary fibrosis is a progressive disease related to damaged lung tissue, making it difficult for patients to breathe and process oxygen effectively. Some lung cancer patients have developed pulmonary fibrosis after radiation, while patients with other cancers have developed it after receiving a specific cancer medication called Bleomycin.

“One of the limiting side effects of thoracic radiotherapy is the development of pulmonary fibrosis in a susceptible subpopulation of treated patients,” said Haston. “However, the specific pathways contributing to fibrosis susceptibility in radiotherapy patients remain unidentified.”

It has been thought that white blood cells, the body’s natural defence mechanism, may contribute to pulmonary fibrosis. Building on this, her research has drawn a connection of Chromosome 6 genes to fibrosis susceptibility, the release said.

She examined the susceptibility to pulmonary fibrosis on lab mice after radiation therapy and on mice after treatment of Bleomycin. The mice with a replaced Chromosome 6 were protected from both radiation-induced and Bleomycin-induced pulmonary fibrosis.

RELATED: Globe trotting biology student to study at UBCO

“The recent findings by our lab have specifically identified these genetic differences to reside in Chromosome 6,” she added, explaining that her work may open the door to individualized cancer treatments, depending on a person’s specific genetic makeup.

Her study, published in Radiation Research, was supported by the Canadian Institutes of Health Research.

“This research aims to develop a pre-treatment marker based on knowledge of specific genes of radiation injury response,” she said. “Such a marker could significantly affect Canadians with cancer, by sparing side effects and increasing the dose to the tumour which may, in turn, increase cure rates.”


edit@kelownacapnews.com

Like us on Facebook and follow us on Twitter.

Just Posted

Hudson Bay Mountain reschedules opening day for Nov. 29, citing warm temperatures, rain

The resort is asking people to upload “snow dance” videos to social media for a chance to win a hoodie

Cuts to provincial policing budget not expected to affect Smithers public saftety: RCMP

Province working with force to address project $10 million budget deficit

B.C. First Nation Chief Ed John faces historic sex charges

John served as minister for children and families under then-premier Ujjah Dosanjh

LNG Canada project gradually taking shape

Extensive worker camp now being assembled

Smithers celebrates 75th anniversary of the Netherlands liberation

Bulkley Valley Christian and Smithers Secondary schools receive gift of tulips

VIDEO: B.C. to restrict nicotine content, bring in 20% tax on vaping products

Province will also restrict candy and fruit flavoured vaping products to adult-only stores

B.C. man facing 18 charges after hidden camera found in Kelowna winery washroom

The camera was found at Summerhill Winery on Aug. 23

No new rules needed to ensure timely youth justice, Supreme Court says

Charter of Rights and Freedoms says someone charged with an offence has the right to be tried within a reasonable time

Seguin lifts surging Stars to 4-2 win over Canucks

Dallas is 6-0-1 in last seven outings

B.C. government working with RCMP to address $10 million in budget cuts

Public Safety Minister Mike Farnworth issues statement following report of RCMP cost-cutting

‘City that protects rapists’: Sexual assault survivor slams Kelowna mayor for defending RCMP

Heather Friesen spent the morning handing out flyers around city hall calling out the mayor

BC Liquor Stores to move fully to paper bags by March

Vancouver Island to be the first to convert to paper bags in November

Tolko shuts B.C. divisions for two weeks over holidays

Head office to close from Dec. 23-27; two weeks’ downtime runs Dec. 21-Jan. 6

Most Read